Guidance Statements

(updated September 2026)

AAALAC International publishes “Guidance Statements” that are used as supplemental requirements or recommendations in dealing with certain issues. 

A. Humane and Responsible Use of Animals

• Acceptance of Exceptions to Guide or other AAALAC Standards
• Application of Performance Standards

B. Compliance with Applicable Regulations

C. Institutional Oversight

• Avoiding Conflicts of Interest in the Leadership and Composition of the IACUC/OB
• Adverse Events
• Evaluation of Scientific Rigor and Experimental Reproducibility
• Frequency of Program Review and Facility Inspection
• Legal Acquisition and Use of Wild-Caught Animals
• Nonaffiliated member of the IACUC
• Non-Pharmaceutical-Grade Compounds
• Post-approval Monitoring of Approved Animal Research Protocols

D. Veterinary Care

• Analgesia and Anesthesia
• Anesthetic Equipment Calibration and Maintenance
• Aseptic Surgery 

E. Personnel Competence and Training

F. Occupational Health and Safety

• Allergy Prevention
• Respiratory Protection

G. Physical Plant and Environment

1)   Animal Environment, Housing, and Management

• Behavioral Management Guidance Statement
• Maintenance of Continuous Mouse Breeding Groups 
  (such as trio breeding or harem breeding) 
• Mouse Cage Sanitation Frequency 
• Transportation of Animals Used in Research

2)   Macroenvironment

• Frequency of Monitoring Rodent Traps
• HVAC Measurements in Agricultural Settings
• Magnetic Resonance (MR) Scanners and Cryogen Gas Storage 
• Temperature & Relative Humidity Control 
• Use of Recirculated Air in Animal Facilities

H. Continuous Improvement